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Solutions

Intelligent → Digital → AI

Achieving intelligent preparation, and expand the innovation

DASEA® Bio-manufacturing Platform

Building the core “new productive capacity” in the CGT

Bottlenecking Problems of 2D

Advantages of DASEA® Bio-manufacturing Platform

Poor control

subjectively ambiguous

Digitalized

digitalization of whole process and consumables

High cost

high labor and consumable costs

Automated

automatic and programable process control

Low efficiency

insufficient use of space

Scalable

3D culture, large single-batch production yield

High risk

open space operation

Enclosed

enclosed system, less contamination

Reduced activity

repeated enzyme digestion

Activated

better cell activity with biomimetic microcarriers

Cost Comparison — DASEA® 3D vs 2D

Expected cell harvest

Type of cultivation

Facility

Time

Labor

Reagent & consumables (thousand yuan)

Total cost (thousand yuan)

1*1010cells

2D

200㎡

1200h

10 pers

19.53

28.32

DASEA® 3D

100㎡

120h

1 pers

9.60

13.30

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90

%

Facility

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90

%

Labour

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80

%

Time

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52

%

Reagents & consumables

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62

%

Total cost

DASEA® Solution for Stem Cell Large-scale Production

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Bio-manufacturing of Mesenchymal Stem Cells (DASEA® 3D vs 2D)

01

Basic properties

Cell morphology / Viability / Cell count

Surface marker analysis of hUMSCs

Human STR profiling identification

Induced in vitro differentiation capacity test (Tri-lineage differentiation)

Chromosomal karyotyping

02

Biological safety

Telomerase activity assay

Soft agar colony formation assay

Nude mouse inoculation test

03

Microbiological safety

Bacterial/Fungal detection

Mycoplasma detection

Adventitious virus testing (Human / Animal-derived)

Endotoxin testing

Lysate residue

Microcarrier lysate residue testing

04

Biological efficacy

Cell secretory factors

Cellular senescence assay

Angiogenesis assay

Fibroblast colony-forming units (CFU-F)

Cell migration

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Pre-Clinical Study

Liver Failure Treatment

Intrauterine Adhesion Treatment

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Progress of Ppre-clinical and clinical trial on stem cells

The statistical data as of Nov 4, 2024

Indications

Mechanism study

Production process

Quality inspection

Pre-clinical study

Investigator-Initiated Trial

Intrauterine adhesions

Intervertebral disc degeneration

Refractory wounds

Acute liver failure

Chronic kidney disease

Tendon injur

Discover regenerative wonders
with REGEN-αGEEK

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