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Solutions

The strategic process of the DASEA Bio-Manufacturing platform “Intelligentized -- Digitalized -- AI"

凭借创新平台,中科睿极实现了细胞与外泌体全自动化与规模化制备,推动着再生医学领域的创新边界。

DASEA Bio-manufacturing Platform
Building the core “new productive capacity” in the CGT

Bottlenecking problems of 2D cell culture technology

Advantages of DASEA Bio-Manufacturing platform

Poor Quality Control

Subjective indicators, experience dependent

Digitalized

digitalization of whole process and consumables

High Fabrication Cost

labor intensive, low utilization rate of consumables

Automated

automatic and programable process control

Low Production Efficiency

insufficient use of space

Scalable

3D culture, large single-batch production yield

High Contamination Risk

open space operation

Enclosed

enclosed system, less contamination

Reduced Cellular Activity

Repeated enzyme digestion

Activated

better cell activity with biomimetic microcarriers

Cost Comparison — DASEA 3D vs 2D

Expected cell harvest

Type of cultivation

Facility

Time

Labor

Reagent & consumables (thousand yuan)

Total cost (thousand yuan)

1*1010cells

2D

200㎡

1200h

10人

19.53

28.32

DASEA 3D

100㎡

120h

1人

9.60

13.30

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90

%

Facility

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90

%

Labour

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80

%

Time

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52

%

Reagents & Consumables

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62

%

Total Cost

DASEA Solution for Stem Cell Large-scale Production

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Bio-manufacturing of Mesenchymal Stem Cells (DASEA 3D vs 2D)

01

Basic Biological Properties

细胞形态 / 活率 / 细胞数

hUMSCs 表面标记物分析

人源STR图谱鉴别

诱导体外分化能力检(三系分化)

染色体核型检查

02

Biological Safety

端粒酶活性检测

软琼脂克隆形成实验

裸鼠体内接种实验

03

Microbiological safety

细菌 / 真菌检测

支原体检测

外源病毒检测(人源 / 动物源)

内毒素检测

裂解液残留

微载体裂解物残留检测

04

Biological Efficacy

细胞分泌因子

细胞衰老实验

血管形成实验

成纤维细胞集落形成单位(CFU-F)

细胞迁移

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Pre-clinical Study

Liver failure treatment

Intrauterine adhesion treatment

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Progress of Pre-clinical and Clinical Trial on stem cells

The statistical data as of Nov 4, 2024

Indications

Mechanism study

Production process

Quality inspection

Pre-clinical animal study

IIT

Intrauterine adhesions

Intervertebral disc degeneration

Refractory wounds

Acute liver failure

Chronic kidney disease

Tendon injur

中科睿极诚邀您一同探索
干细胞与外泌体的无限可能

中科睿极 公众号
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DASEA Lab 公众号
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友情链接

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